112921-07-0
Chemical Structure
D-Ala-AMS
- CAS No.: 112921-07-0
- Formula:C13H19N7O7S
- Molecular Weight:417.40
InChIKey: CWWYMWDIYBJVLP-ZOBJURTISA-N
SMILES: NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COS(NC([C@H](N)C)=O)(=O)=O)O3
Biological Activity: D-Ala-AMS is an enzyme inhibitor with activity against cysteine adenylation domains and D-alanine adenylation enzymes. D-Ala-AMS mimics the cognate D-alanyl-AMP reaction intermediate and blocks the adenylation activity of its targets. D-Ala-AMS blocks the recovery of bacterial growth in the presence of Vancomycin. D-Ala-AMS can be used in studies related to Gram-positive bacterial infections[1][2].
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D-Ala-AMS | D-Ala-AMS is an enzyme inhibitor with activity against cysteine adenylation domains and D-alanine adenylation enzymes. D-Ala-AMS mimics the cognate D-alanyl-AMP reaction intermediate and blocks the adenylation activity of its targets. D-Ala-AMS blocks the recovery of bacterial growth in the presence of Vancomycin. D-Ala-AMS can be used in studies related to Gram-positive bacterial infections. | |||||||||||||||||||||
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- [1]. Cisar JS, et al. Exploiting ligand conformation in selective inhibition of non-ribosomal peptide synthetase amino acid adenylation with designed macrocyclic small molecules. Journal of the American Chemical Society. 2007 Jun 27;129(25):7752-3.
- [2]. Cisar JS, et al. Small molecule inhibition of microbial natural product biosynthesis-an emerging antibiotic strategy. Chemical Society reviews. 2008 Jul;37(7):1320-9.
Keywords
