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Cat. No.: HY-188005

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D-Ala-AMS

D-Ala-AMS is an enzyme inhibitor with activity against cysteine adenylation domains and D-alanine adenylation enzymes. D-Ala-AMS mimics the cognate D-alanyl-AMP reaction intermediate and blocks the adenylation activity of its targets. D-Ala-AMS blocks the recovery of bacterial growth in the presence of Vancomycin. D-Ala-AMS can be used in studies related to Gram-positive bacterial infections.

For research use only. We do not sell to patients.

CAS No.: 112921-07-0
Formula: C₁₃H₁₉N₇O₇S
Molecular Weight:417.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

D-Ala-AMS Chemical Structure

CAS No.: 112921-07-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

D-Ala-AMS (Compound 1d) inhibits the cysteine adenylation domain of Yersinia pestis HMWP2 with a K_i^app value of 34 μM^[1].
D-Ala-AMS inhibits DltA from Bacillus subtilis with a K_i of 232 nM^[2].
D-Ala-AMS (1 mM) enhances the activity of 0.4 nM Vancomycin (HY-B0671) against Bacillus subtilis by blocking bacterial growth recovery^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 112921-07-0
Molecular Weight 417.40
Formula C₁₃H₁₉N₇O₇S
SMILES

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COS(NC([C@H](N)C)=O)(=O)=O)O3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cisar JS, et al. Exploiting ligand conformation in selective inhibition of non-ribosomal peptide synthetase amino acid adenylation with designed macrocyclic small molecules. Journal of the American Chemical Society. 2007 Jun 27;129(25):7752-3.

[2]. Cisar JS, et al. Small molecule inhibition of microbial natural product biosynthesis-an emerging antibiotic strategy. Chemical Society reviews. 2008 Jul;37(7):1320-9.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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