1131456-28-4
1131456-28-4
Chemical Structure
KGP94
- CAS No.: 1131456-28-4
- Formula:C14H12BrN3OS
- Molecular Weight:350.23
IUPAC Name: (Z)-2-((3-bromophenyl)(3-hydroxyphenyl)methylene)hydrazine-1-carbothioamide
InChIKey: ZDBKSZKTCPOBFR-GHRIWEEISA-N
SMILES: S=C(N/N=C(C1=CC(O)=CC=C1)\C2=CC(Br)=CC=C2)N
Biological Activity: KGP94 is a selective inhibitor of cathepsin L with an IC50 of 189 nM[1]. KGP94 inhibits migration and invasion of metastatic carcinoma and shows low cytotoxicity (GI50=26.9 µM) against various human cell lines[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KGP94 | 99.77% | KGP94 is a selective inhibitor of cathepsin L with an IC50 of 189 nM. KGP94 inhibits migration and invasion of metastatic carcinoma and shows low cytotoxicity (GI50=26.9 µM) against various human cell lines. | ||||||||||||||||||||
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References
- [1]. Parker EN, et al. Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L. Bioorg Med Chem Lett. 2017 Mar 1. 27(5):1304-1310. [Content Brief]
- [2]. Munikishore R, et al. An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of cathepsin L: KGP94. Bioorg Chem. 2021 Nov. 116:105317. [Content Brief]
Keywords
