113476-61-2
Chemical Structure
Gymnopusin
- CAS No.: 113476-61-2
- Formula:C17H16O5
- Molecular Weight:300.31
IUPAC Name: 3,4,9-trimethoxyphenanthrene-2,7-diol
InChIKey: GIVSZLKTIBWYRM-UHFFFAOYSA-N
SMILES: OC(C=CC1=C2C(OC)=C(OC)C(O)=CC2=C3)=CC1=C3OC
Biological Activity: Gymnopusin is an L-type voltage-dependent calcium channel blocker and vasorelaxant. Gymnopusin inhibits KCl- and Norepinephrine-induced contractility as well as CaCl2-induced contractions. Gymnopusin induces endothelium-independent relaxation involving the opening of ATP-sensitive and calcium-activated potassium channels. Gymnopusin disrupts membranes through tonoplast lysis, leading to electrolyte leakage, chlorophyll loss, and photobleaching in duckweed. Gymnopusin inhibits radicle elongation in Amaranthus hypochondriacus seedlings and exhibits phytotoxicity against duckweed. Gymnopusin shows moderate cytotoxicity against mammalian cell lines. Gymnopusin can be used for research on hypertension[1].
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Gymnopusin | Gymnopusin is an L-type voltage-dependent calcium channel blocker and vasorelaxant. Gymnopusin inhibits KCl- and Norepinephrine-induced contractility as well as CaCl2-induced contractions. Gymnopusin induces endothelium-independent relaxation involving the opening of ATP-sensitive and calcium-activated potassium channels. Gymnopusin disrupts membranes through tonoplast lysis, leading to electrolyte leakage, chlorophyll loss, and photobleaching in duckweed. Gymnopusin inhibits radicle elongation in Amaranthus hypochondriacus seedlings and exhibits phytotoxicity against duckweed. Gymnopusin shows moderate cytotoxicity against mammalian cell lines. Gymnopusin can be used for research on hypertension. | |||||||||||||||||||||
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