115626-67-0
Chemical Structure
OM-4842
- CAS No.: 115626-67-0
- Formula:C37H46O14
- Molecular Weight:714.75
InChIKey: NXMILGRUJOPZOM-WCWCMWHBSA-N
SMILES: O=C(C1=C(O)C([C@H]2C[C@H]([C@@H]([C@H](O2)C)O)O[C@@H]3O[C@H]([C@H](CC3)O)C)=CC=C1C4=O)C(C=C[C@@]5(C[C@@](O)(CC6=O)C)O)=C4[C@]56O[C@@H]7O[C@H]([C@H](CC7)O)C
Biological Activity: OM-4842 is an ansamycin antibiotic and platelet aggregation inhibitor derived from Streptomyces. OM-4842 inhibits platelet aggregation induced by Adenosine 5'-diphosphate (ADP) (HY-W010918), Arachidonic acid (HY-109590), and C16-PAF (PAF) (HY-108635), and exerts growth-inhibitory activity against Doxorubicin (HY-15142A)-resistant P388 mouse leukemia cells. OM-4842 is used in research on platelet aggregation-related disorders and drug-resistant leukemia[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
OM-4842 | OM-4842 is an ansamycin antibiotic and platelet aggregation inhibitor derived from Streptomyces. OM-4842 inhibits platelet aggregation induced by Adenosine 5'-diphosphate (ADP) (HY-W010918), Arachidonic acid (HY-109590), and C16-PAF (PAF) (HY-108635), and exerts growth-inhibitory activity against Doxorubicin (HY-15142A)-resistant P388 mouse leukemia cells. OM-4842 is used in research on platelet aggregation-related disorders and drug-resistant leukemia. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Omura S, et al. OM-4842, a new platelet aggregation inhibitor from Streptomyces. J Antibiot (Tokyo). 1988 Jun;41(6):812-3.
- [2]. Gyorgyi Udvarnoki, et al. Biosynthetic origin of the oxygen atoms of aquayamycin: aspects for the biosynthesis of the urdamycin family and for aquayamycin-containing angucycline antibiotics in general. Journal of Organic Chemistry 1 February 1992; 57 (4): 1274–1276.
- [3]. Liu HS, et al. Bioactive Angucyclines/Angucyclinones Discovered from 1965 to 2023. Marine drugs. 2025 Jan 05;23(1):25.