OM-4842
OM-4842 is an ansamycin antibiotic and platelet aggregation inhibitor derived from Streptomyces. OM-4842 inhibits platelet aggregation induced by Adenosine 5'-diphosphate (ADP) (HY-W010918), Arachidonic acid (HY-109590), and C16-PAF (PAF) (HY-108635), and exerts growth-inhibitory activity against Doxorubicin (HY-15142A)-resistant P388 mouse leukemia cells. OM-4842 is used in research on platelet aggregation-related disorders and drug-resistant leukemia.
For research use only. We do not sell to patients.
- CAS No.: 115626-67-0
- Formula: C37H46O14
- Molecular Weight:714.75
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| P388/ADR | MIC |
1.5 μg/mL
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Cytotoxicity against doxorubicin-resistant P388 mouse leukemia cells, quantified as inhibition of cell growth.
Cytotoxicity against doxorubicin-resistant P388 mouse leukemia cells, quantified as inhibition of cell growth.
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39852527 |
| Platelet | MIC |
5.0 μg/mL
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Inhibition of ADP-induced platelet aggregation in cultured platelets.
Inhibition of ADP-induced platelet aggregation in cultured platelets.
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39852527 |
| Platelet | MIC |
12.5 μg/mL
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Inhibition of arachidonic acid-induced platelet aggregation in cultured platelets.
Inhibition of arachidonic acid-induced platelet aggregation in cultured platelets.
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39852527 |
| Platelet | MIC |
25 μg/mL
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Inhibition of PAF- or collagen-induced platelet aggregation in cultured platelets.
Inhibition of PAF- or collagen-induced platelet aggregation in cultured platelets.
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39852527 |
In Vitro
OM-4842 (1.5 μg/mL; 72 h) inhibits the growth of Doxorubicin (HY-15142A)-resistant P388 murine leukemia cells in vitro[1].
OM-4842 (compound 143) (1.5 µg/mL) inhibits the growth of Doxorubicin-resistant P388 mouse leukemia cells[3].
OM-4842 (compound 3) is an intermediate in the urdamycin biosynthetic pathway in Streptomyces fradiae (strain Tu 2717). It is produced from aquayamycin and subsequently converted to urdamycin A[2].
OM-4842 (5.0-25 µg/mL) inhibits platelet aggregation induced by ADP, arachidonic acid, PAF, and collagen, with MIC50 values of 5.0, 12.5, and 25 µg/mL, respectively[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:doxorubicin-resistant P388 mouse leukemia cells
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Concentration:1.5 μg/mL
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Incubation Time:72 h
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Result:Inhibited the growth of Doxorubicin-resistant P388 mouse leukemia cells.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ddY mice[1]
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Dosage:200 μg/kg
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Administration:i.v.
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Result:Reached an acute toxicity LD50 of approximately 200 μg/kg.
Chemical Information
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CAS No. 115626-67-0
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Molecular Weight 714.75
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Formula C37H46O14
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SMILES
O=C(C1=C(O)C([C@H]2C[C@H]([C@@H]([C@H](O2)C)O)O[C@@H]3O[C@H]([C@H](CC3)O)C)=CC=C1C4=O)C(C=C[C@@]5(C[C@@](O)(CC6=O)C)O)=C4[C@]56O[C@@H]7O[C@H]([C@H](CC7)O)C
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Structure Classification
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Initial Source
Streptomyces
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
OM-4842 Related Classifications
HY-N21816 Related Classifications
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