115956-13-3
115956-13-3
Chemical Structure
Dolasetron Mesylate
Synonym(s): MDL-73147EF
- CAS No.: 115956-13-3
- Formula:C20H24N2O6S
- Molecular Weight:420.48
IUPAC Name: (5s,6R,8r,9aS)-3-oxooctahydro-2H-2,6-methanoquinolizin-8-yl 1H-indole-3-carboxylate methanesulfonate
InChIKey: PSGRLCOSIXJUAL-ARYLMGLASA-N
SMILES: O=C(C1=CNC2=C1C=CC=C2)O[C@@H]3C[C@@](CC4C5)([H])[N@](CC4=O)[C@@]5([H])C3.O=S(C)(O)=O
Biological Activity: Dolasetron Mesylate (MDL-73147EF) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy[1][2].
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Dolasetron Mesylate | Dolasetron Mesylate (MDL-73147EF) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy. | |||||||||||||||||||||
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References
- [1]. Faria C, et al. Outcomes Associated with 5-HT3-RA Therapy Selection in Patients with Chemotherapy-Induced Nausea and Vomiting: A Retrospective Claims Analysis. Am Health Drug Benefits. 2014 Jan;7(1):50-8. [Content Brief]
- [2]. Schwartzberg L, et al. Pooled analysis of phase III clinical studies of palonosetron versus ondansetron, dolasetron, and granisetron in the prevention of chemotherapy-induced nausea and vomiting (CINV). Support Care Cancer. 2014;22(2):469-477. [Content Brief]
