1160952-43-1
Chemical Structure
KU-177
- CAS No.: 1160952-43-1
- Formula:C27H23NO8
- Molecular Weight:489.47
IUPAC Name: 5-(3',6-dimethoxy-[1,1'-biphenyl]-3-yl)-1-(4-(trifluoromethyl)phenyl)-1H-tetrazole
InChIKey: DKZHANZAVOELPJ-UHFFFAOYSA-N
SMILES: COC1=CC(C2=C(C=CC(C(NC3=CC4=CC=C(C(OC)=C4OC3=O)OC(C)=O)=O)=C2)OC)=CC=C1
Biological Activity: KU-177 is a potent inhibitor of Hsp90 ATPase homologue 1 (Aha1), ablates Aha1-driven enhancement of Hsp90-dependent tau aggregation. KU-177 also disrupts Aha1/Hsp90 interactions (IC50=4.08 μM) without inhibition of Hsp90’s ATPase activity. KU-177 can be used for tauopathies research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KU-177 | KU-177 is a potent inhibitor of Hsp90 ATPase homologue 1 (Aha1), ablates Aha1-driven enhancement of Hsp90-dependent tau aggregation. KU-177 also disrupts Aha1/Hsp90 interactions (IC50=4.08 μM) without inhibition of Hsp90’s ATPase activity. KU-177 can be used for tauopathies research. | |||||||||||||||||||||
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- [1]. Gu C, et al. AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma. J Exp Clin Cancer Res. 2022 Jan 6;41(1):11. [Content Brief]
- [2]. Keegan BM, et al. Synthesis and Evaluation of Small Molecule Disruptors of the Aha1/Hsp90 Complex for the Reduction of Tau Aggregation. ACS Med Chem Lett. 2022 Apr 15;13(5):827-832. [Content Brief]
Keywords
