1173022-55-3
1173022-55-3
Chemical Structure
1,3,7-Trimethyluric acid-13C4,15N3
- CAS No.: 1173022-55-3
- Formula:C413C4H10N15N3O3
- Molecular Weight:217.14
InChIKey: BYXCFUMGEBZDDI-TWHZHSGKSA-N
SMILES: C[15N]1[13C]2=[13C](N(C([15NH]2)=O)C)[13C]([15N]([13C]1=O)C)=O
Biological Activity: 1,3,7-Trimethyluric acid-13C4,15N3 is the 13C and 15N labeled 1,3,7-Trimethyluric acid[1]. 1,3,7-Trimethyluric acid is the metabolite of caffeine. The metabolic ratio 1,3,7-Trimethyluric acid to caffeine can be evaluated as a biomarker to describe variability in CYP3A activity in a cohort[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
1,3,7-Trimethyluric acid-13C4,15N3 | 1,3,7-Trimethyluric acid-13C4,15N3 is the 13C and 15N labeled 1,3,7-Trimethyluric acid. 1,3,7-Trimethyluric acid is the metabolite of caffeine. The metabolic ratio 1,3,7-Trimethyluric acid to caffeine can be evaluated as a biomarker to describe variability in CYP3A activity in a cohort. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
1,3,7-Trimethyluric acid (Standard) | ≥98% | Hederagenin (Standard) is the analytical standard of Hederagenin. This product is intended for research and analytical applications. Hederagenin is a triterpenoid saponin with orally active and antitumor activity. Hederagenin can inhibit the expression of iNOS, COX-2, and NF-κB in cells induced by LPS stimulation. Hederagenin also increases ROS production in cancer cells, disrupts mitochondrial membrane potential, and induces apoptosis. Hederagenin also sensitizes cancer cells to Cisplatin (HY-17394) and Paclitaxel (HY-B0015), enhancing induced apoptosis. Hederagenin also has preventive potential against alcoholic liver injury. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
1,3,7-Trimethyluric acid-d9 | 1,3,7-Trimethyluric acid-d9 is the deuterium labeled 1,3,7-Trimethyluric acid. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
1,3,7-Trimethyluric acid | 99.99% | 1,3,7-Trimethyluric acid is the metabolite of caffeine. The metabolic ratio 1,3,7-Trimethyluric acid to caffeine can be evaluated as a biomarker to describe variability in CYP3A activity in a cohort. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Y Benchekroun, et al. Isotopic effects on retention times of caffeine and its metabolites 1,3,7-trimethyluric acid, theophylline, theobromine and paraxanthine. J Chromatogr B Biomed Sci Appl. 1997 Jan 24;688(2):245-54. [Content Brief]
