1175077-25-4
1175077-25-4
Chemical Structure
LYG-202
- CAS No.: 1175077-25-4
- Formula:C25H30N2O5
- Molecular Weight:438.52
IUPAC Name: 5-hydroxy-8-methoxy-7-(4-(4-methylpiperazin-1-yl)butoxy)-2-phenyl-4H-chromen-4-one
InChIKey: ICGYSEWPMDWBIL-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC=CC=C2)OC3=C(OC)C(OCCCCN4CCN(C)CC4)=CC(O)=C13
Biological Activity: LYG-202, a flavonoid, has potent anti-angiogenic and antitumor activity. LYG-202 inhibits VEGF-stimulated HUVEC migration and tube formation. LYG-202 induces cancer cell apoptosis[1][2].
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LYG-202 | 99.04% | LYG-202, a flavonoid, has potent anti-angiogenic and antitumor activity. LYG-202 inhibits VEGF-stimulated HUVEC migration and tube formation. LYG-202 induces cancer cell apoptosis. | ||||||||||||||||||||
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References
- [1]. Chen Y, et al. LYG-202, a newly synthesized flavonoid, exhibits potent anti-angiogenic activity in vitro and in vivo. J Pharmacol Sci. 2010;112(1):37-45. [Content Brief]
- [2]. Zhao Y, et al. LYG-202 exerts antitumor effect on PI3K/Akt signaling pathway in human breast cancer cells. Apoptosis. 2015 Sep;20(9):1253-69. [Content Brief]
