1185168-06-2
Chemical Structure
N-Desmethyl Sildenafil-d8
Synonym(s): Desmethylsildenafil-d8;UK-103,320-d8
- CAS No.: 1185168-06-2
- Formula:C21H20D8N6O4S
- Molecular Weight:468.60
IUPAC Name: 5-(2-ethoxy-5-((piperazin-1-yl-2,2,3,3,5,5,6,6-d8)sulfonyl)phenyl)-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
InChIKey: UZTKBZXHEOVDRL-PMCMNDOISA-N
SMILES: CCCC1=NN(C)C2=C1NC(C3=C(C=CC(S(=O)(N4C([2H])([2H])C([2H])([2H])NC([2H])([2H])C4([2H])[2H])=O)=C3)OCC)=NC2=O
Biological Activity: N-Desmethyl Sildenafil-d8 is the deuterium labeled N-Desmethyl Sildenafil (HY-117605). N-Desmethyl Sildenafil is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor[1][2][3].
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N-Desmethyl Sildenafil-d8 | N-Desmethyl Sildenafil-d8 is the deuterium labeled N-Desmethyl Sildenafil (HY-117605). N-Desmethyl Sildenafil is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor. | |||||||||||||||||||||
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N-Desmethyl Sildenafil (Standard) | 98.82% | N-Desmethyl Sildenafil (Standard) is the analytical standard of N-Desmethyl Sildenafil. This product is intended for research and analytical applications. N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor. | ||||||||||||||||||||
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N-Desmethyl Sildenafil | 99.60% | N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor. | ||||||||||||||||||||
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- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Péter Barabás, et al. Sildenafil, N-desmethyl-sildenafil and Zaprinast enhance photoreceptor response in the isolated rat retina. Neurochem Int. 2003 Nov;43(6):591-5. [Content Brief]
- [3]. Rikako Takahiro, et al. Contribution of CYP3A isoforms to dealkylation of PDE5 inhibitors: a comparison between sildenafil N-demethylation and tadalafil demethylenation. Biol Pharm Bull. 2015;38(1):58-65. [Content Brief]
