1186026-25-4
Chemical Structure
Pyronaridine-d4 tetraphosphate
- CAS No.: 1186026-25-4
- Formula:C29H40D4ClN5O18P4
- Molecular Weight:914.06
IUPAC Name: 4-((7-chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino)-2,6-bis(pyrrolidin-1-ylmethyl-d2)phenol tetrakis(phosphate)
InChIKey: YKUQEKXHQFYULM-JPJNPXIZSA-N
SMILES: O=P(O)(O)O.ClC1=CC2=C(C=C1)C(NC3=CC(C([2H])([2H])N4CCCC4)=C(C(C([2H])([2H])N5CCCC5)=C3)O)=C6C(C=CC(OC)=N6)=N2.O=P(O)(O)O.O=P(O)(O)O.O=P(O)(O)O
Biological Activity: Pyronaridine-d4 (tetraphosphate) is the deuterium labeled Pyronaridine tetraphosphate[1]. Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection[2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Pyronaridine-d4 tetraphosphate | 97.00% | Pyronaridine-d4 (tetraphosphate) is the deuterium labeled Pyronaridine tetraphosphate. Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection. | ||||||||||||||||||||
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Pyronaridine tetraphosphate (Standard) | ≥98% | Pyronaridine (tetraphosphate) (Standard) is the analytical standard of Pyronaridine (tetraphosphate). This product is intended for research and analytical applications. Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection. | ||||||||||||||||||||
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Pyronaridine-13C2,d4 tetraphosphate | Pyronaridine tetraphosphate-13C2,d4 is the deuterium and 13C-labeled Pyronaridine tetraphosphate (HY-14749A). Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection. | |||||||||||||||||||||
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Pyronaridine tetraphosphate | 99.57% | Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection. | ||||||||||||||||||||
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- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Vivas L, et al. Anti-malarial efficacy of pyronaridine and artesunate in combination in vitro and in vivo. Acta Trop. 2008 Mar;105(3):222-8. [Content Brief]
- [3]. Jun Li, et al. Old drug repurposing for neglected disease: Pyronaridine as a promising candidate for the treatment of Echinococcus granulosus infections. EBioMedicine. 2020 Apr;54:102711. [Content Brief]
