1189865-34-6
Chemical Structure
Diethyl butylmalonate-d9
- CAS No.: 1189865-34-6
- Formula:C11H11D9O4
- Molecular Weight:225.33
IUPAC Name: diethyl 2-(butyl-d9)malonate
InChIKey: RPNFNBGRHCUORR-GQWSVURBSA-N
SMILES: O=C(OCC)C(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])C(OCC)=O
Biological Activity: Diethyl butylmalonate-d9 is the deuterium labeled Diethyl butylmalonate (HY-44178). Diethyl butylmalonate is a competitive inhibitor of succinate dehydrogenase. Diethyl butylmalonate exerts anti-inflammatory effects by inhibiting ROS production. Diethyl butylmalonate also has neuroprotective activity. In addition, Diethyl butylmalonate shows toxicity to T. pyriformis, with its log(IGC50-1) being 0.557. Diethyl butylmalonate can be used in the research of diseases such as Alzheimer's disease[1][2].
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Diethyl butylmalonate-d9 | 98% | Diethyl butylmalonate-d9 is the deuterium labeled Diethyl butylmalonate (HY-44178). Diethyl butylmalonate is a competitive inhibitor of succinate dehydrogenase. Diethyl butylmalonate exerts anti-inflammatory effects by inhibiting ROS production. Diethyl butylmalonate also has neuroprotective activity. In addition, Diethyl butylmalonate shows toxicity to T. pyriformis, with its log(IGC50-1) being 0.557. Diethyl butylmalonate can be used in the research of diseases such as Alzheimer's disease. | ||||||||||||||||||||
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Diethyl butylmalonate | 99.56% | Diethyl butylmalonate is a competitive inhibitor of succinate dehydrogenase. Diethyl butylmalonate exerts anti-inflammatory effects by inhibiting ROS production. Diethyl butylmalonate also has neuroprotective activity. In addition, Diethyl butylmalonate shows toxicity to T. pyriformis, with its log(IGC50-1) being 0.557. Diethyl butylmalonate can be used in the research of diseases such as Alzheimer's disease. | ||||||||||||||||||||
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- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. T I Netzeva, et al. Partial least squares modelling of the acute toxicity of aliphatic compounds to Tetrahymena pyriformis. SAR QSAR Environ Res. 2003 Aug;14(4):265-83. [Content Brief]
