120382-04-9
Chemical Structure
RU-39411
- CAS No.: 120382-04-9
- Formula:C28H37NO3
- Molecular Weight:435.60
IUPAC Name: (8S,9R,11S,13S,14S,17S)-11-(4-(2-(dimethylamino)ethoxy)phenyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
InChIKey: VBPPJMXMMHJPDP-JZFZMOLRSA-N
SMILES: C[C@@]12[C@H](CC[C@]1([C@@]3(CCC4=C([C@]3([C@H](C2)C5=CC=C(C=C5)OCCN(C)C)[H])C=CC(O)=C4)[H])[H])O
Biological Activity: RU-39411 is a steroidal anti-estrogen with mixed estrogenic/antiestrogen activity. RU-39411 has shown inhibitory effects on cell growth in the MCF-7 breast cancer model, with the effect being correlated with its binding affinity to the estrogen receptor. RU-39411 was able to downregulate the estrogen binding capacity of cells, but did not reduce estrogen receptor mRNA levels, indicating that the grafting of its side chain prevents the antagonistic effects usually associated with steroidal estrogens. The administration of RU-39411 can promote the synthesis of progesterone receptors, further supporting its activity as an estrogen[1].
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RU-39411 | RU-39411 is a steroidal anti-estrogen with mixed estrogenic/antiestrogen activity. RU-39411 has shown inhibitory effects on cell growth in the MCF-7 breast cancer model, with the effect being correlated with its binding affinity to the estrogen receptor. RU-39411 was able to downregulate the estrogen binding capacity of cells, but did not reduce estrogen receptor mRNA levels, indicating that the grafting of its side chain prevents the antagonistic effects usually associated with steroidal estrogens. The administration of RU-39411 can promote the synthesis of progesterone receptors, further supporting its activity as an estrogen. | |||||||||||||||||||||
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Keywords
