121346-32-5
Chemical Structure
SR33805 analog
- CAS No.: 121346-32-5
- Formula:C32H40N2O5S
- Molecular Weight:564.74
IUPAC Name: N-(3,4-dimethoxyphenethyl)-3-(4-((3-isopropyl-1-methyl-1H-indol-2-yl)sulfonyl)phenoxy)-N-methylpropan-1-amine
InChIKey: GCVFQRRBTCHIPK-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(C=C1)OCCCN(CCC2=CC=C(C(OC)=C2)OC)C)(C(N3C)=C(C4=C3C=CC=C4)C(C)C)=O
Biological Activity: SR 33805 (analog) is an orally active Ca2+ channel blocker that selectively inhibits the proliferation of smooth muscle cells. SR 33805 (analog) reduces calcium uptake by blocking calcium channels, thereby inhibiting smooth muscle cell proliferation induced by serum, platelet-derived growth factor, and basic fibroblast growth factor. SR 33805 (analog) significantly reduces intimal thickening following endothelial injury in rabbits. SR 33805 (analog) shows promise for cardiovascular disease research, such as in early atherosclerosis[1].
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SR33805 analog | SR 33805 (analog) is an orally active Ca2+ channel blocker that selectively inhibits the proliferation of smooth muscle cells. SR 33805 (analog) reduces calcium uptake by blocking calcium channels, thereby inhibiting smooth muscle cell proliferation induced by serum, platelet-derived growth factor, and basic fibroblast growth factor. SR 33805 (analog) significantly reduces intimal thickening following endothelial injury in rabbits. SR 33805 (analog) shows promise for cardiovascular disease research, such as in early atherosclerosis. | |||||||||||||||||||||
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Keywords
