1225383-40-3
Chemical Structure
PROTAC CRABP-II Degrader-1
- CAS. Nr.: 1225383-40-3
- Formula:C42H60N4O9
- Molecular Weight:764.95
IUPAC Name: (2E,4E,6E,8E)-9-((E)-3-((((11S,14S,15R)-15-amino-14-hydroxy-11-isobutyl-2,10,13-trioxo-16-phenyl-6,9-dioxa-3,12-diazahexadecyl)oxy)imino)-2,6,6-trimethylcyclohex-1-en-1-yl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
InChIKey: XEMRMMAFXLINDA-XVCXXHFGSA-N
SMILES: CC(/C=C/C=C(/C=C/C1=C(/C(CCC(C)1C)=N/OCC(NCCOCCOC([C@H](CC(C)C)NC([C@@H](O)[C@H](N)CC2=CC=CC=C2)=O)=O)=O)C)C)=C\C(O)=O
Biological Activity: PROTAC CRABP-II Degrader-1 is a cellular retinoic acid-binding protein (CRABP-II) SNIPER degrader. PROTAC CRABP-II Degrader-1 hijacks the cIAP1 E3 ligase to induce ubiquitination and proteasomal degradation of CRABP-II. PROTAC CRABP-II Degrader-1 can be used for the research of neuroblastoma[1].
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PROTAC CRABP-II Degrader-1 | PROTAC CRABP-II Degrader-1 is a cellular retinoic acid-binding protein (CRABP-II) SNIPER degrader. PROTAC CRABP-II Degrader-1 hijacks the cIAP1 E3 ligase to induce ubiquitination and proteasomal degradation of CRABP-II. PROTAC CRABP-II Degrader-1 can be used for the research of neuroblastoma. | |||||||||||||||||||||
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