122855-18-9
122855-18-9
Chemical Structure
Enzyme-IN-3 disodium
- CAS No.: 122855-18-9
- Formula:C20H13N3Na2O8S2
- Molecular Weight:533.44
IUPAC Name: sodium (E)-7-amino-4-hydroxy-3-((5-hydroxy-7-sulfonatonaphthalen-2-yl)diazenyl)naphthalene-2-sulfonate
InChIKey: ISVGEQZXHOLKRA-VPMNAVQSSA-L
SMILES: O=S(C1=C(/N=N/C2=CC=C3C(O)=CC(S(=O)(O[Na])=O)=CC3=C2)C(O)=C4C=CC(N)=CC4=C1)(O[Na])=O
Biological Activity: Enzyme-IN-3 disodium (compound 7) is a selective inhibitor of Mycobacterium tuberculosis shikimate kinase with an IC50 of 1.6 μM. Enzyme-IN-3 disodium has antibacterial activity[1][2].
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Enzyme-IN-3 disodium | Enzyme-IN-3 disodium (compound 7) is a selective inhibitor of Mycobacterium tuberculosis shikimate kinase with an IC50 of 1.6 μM. Enzyme-IN-3 disodium has antibacterial activity. | |||||||||||||||||||||
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References
- [1]. Gordon S, et al. Selective Mycobacterium tuberculosis Shikimate Kinase Inhibitors as Potential Antibacterials. Perspect Medicin Chem. 2015 Mar 15;7:9-20. [Content Brief]
- [2]. Prado V, et al. Targeting the Motion of Shikimate Kinase: Development of Competitive Inhibitors that Stabilize an Inactive Open Conformation of the Enzyme. J Med Chem. 2016 Jun 9;59(11):5471-87. [Content Brief]
Keywords
