1228660-00-1
Chemical Structure
LEI-101 free base
- CAS No.: 1228660-00-1
- Formula:C23H25FN4O4S
- Molecular Weight:472.53
IUPAC Name: 3-cyclopropyl-1-(4-(6-((1,1-dioxidothiomorpholino)methyl)-5-fluoropyridin-2-yl)benzyl)imidazolidine-2,4-dione
InChIKey: XUZTUGWOFAKLPB-UHFFFAOYSA-N
SMILES: O=C1N(C(CN1CC2=CC=C(C=C2)C3=NC(CN(CC4)CCS4(=O)=O)=C(C=C3)F)=O)C5CC5
Biological Activity: LEI-101 free base is a selective and orally bioavailable CB2 receptor agonist with the potential to inhibit diseases associated with inflammation and/or oxidative stress. LEI-101 free base has a binding potency to CB2 receptors that is approximately 100 times higher than that to CB1 receptors. Its pEC50 value on CB2 receptors is 8, while its pKi value on hERG is less than 4. LEI-101 may have an inhibitory effect on conditions such as kidney disease[1].
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LEI-101 free base | LEI-101 free base is a selective and orally bioavailable CB2 receptor agonist with the potential to inhibit diseases associated with inflammation and/or oxidative stress. LEI-101 free base has a binding potency to CB2 receptors that is approximately 100 times higher than that to CB1 receptors. Its pEC50 value on CB2 receptors is 8, while its pKi value on hERG is less than 4. LEI-101 may have an inhibitory effect on conditions such as kidney disease. | |||||||||||||||||||||
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Keywords
