1231148-54-1
Chemical Structure
Flibanserin salicylate
Synonym(s): BIMT-17 salicylate; BIMT-17BS salicylate
- CAS No.: 1231148-54-1
- Formula:C27H27F3N4O4
- Molecular Weight:528.52
InChIKey: CCZODSYDHFPMNP-UHFFFAOYSA-N
SMILES: O=C1NC2=C(N1CCN3CCN(CC3)C4=CC=CC(C(F)(F)F)=C4)C=CC=C2.OC(C5=CC=CC=C5O)=O
Biological Activity: Flibanserin (BIMT-17) salicylate is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with Ki values of 1 nM and 49 nM, respectively. Flibanserin salicylate binds to dopamine D4 receptors with an Ki value of 4-24 nM. Flibanserin salicylate shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research[1]-[5].
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Flibanserin salicylate | Flibanserin (BIMT-17) salicylate is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with Ki values of 1 nM and 49 nM, respectively. Flibanserin salicylate binds to dopamine D4 receptors with an Ki value of 4-24 nM. Flibanserin salicylate shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research-. | |||||||||||||||||||||
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- [1]. Fayed M, et al. Insights into Flibanserin Oxidative Stress Degradation Pathway: In Silico – In Vitro Toxicity Assessment of Its Degradates[J]. New Journal of Chemistry, 2021.
- [5]. Gelman F, et al. Flibanserin for hypoactive sexual desire disorder: place in therapy. Ther Adv Chronic Dis. 2017 Jan;8(1):16-25. [Content Brief]
Keywords
