1231767-35-3
Chemical Structure
CB-182804
- CAS No.: 1231767-35-3
- Formula:C54H86ClN17O13
- Molecular Weight:1216.82
IUPAC Name: (S)-4-amino-N-((2S,3R)-1-(((S)-4-amino-1-oxo-1-(((3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-((R)-1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl)amino)butan-2-yl)amino)-3-hydroxy-1-oxobutan-2-yl)-2-(3-(2-chlorophenyl)ureido)butanamide
InChIKey: OINMSSZOBLWDTB-LDPSCSCQSA-N
SMILES: O=C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@]([C@H](O)C)([H])C(NCC[C@@](NC([C@H](CCN)NC([C@@]([C@H](O)C)([H])NC([C@H](CCN)NC(NC1=C(C=CC=C1)Cl)=O)=O)=O)=O)([H])C(N[C@@H](CCN)C2=O)=O)=O)=O)CCN)=O)([H])CCN)=O)CC(C)C)[C@H](N2)CC3=CC=CC=C3
Biological Activity: CB-182804, Polymyxin B (HY-149179) analogue, is a polypeptide antibiotic. CB-182804 has inhibitory activity against all Gram-negative pathogenic bacteria, including Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa with MIC50 values of 2 μg/mL. CB-182804 is mainly used for the research on refractory infections caused by multidrug-resistant (MDR) Gram-negative bacteria[1].
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CB-182804 | CB-182804, Polymyxin B (HY-149179) analogue, is a polypeptide antibiotic. CB-182804 has inhibitory activity against all Gram-negative pathogenic bacteria, including Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa with MIC50 values of 2 μg/mL. CB-182804 is mainly used for the research on refractory infections caused by multidrug-resistant (MDR) Gram-negative bacteria. | |||||||||||||||||||||
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Keywords
