124097-52-5
Chemical Structure
BRL-41992
- CAS No.: 124097-52-5
- Formula:C18H20N2
- Molecular Weight:264.36
IUPAC Name: (1R,13bS)-1,2-dimethyl-2,3,9,13b-tetrahydro-1H-dibenzo[c,f]imidazo[1,5-a]azepine
InChIKey: UXCGGTCHSALBPY-FZKQIMNGSA-N
SMILES: CN(CN1[C@]2(C3=CC=CC=C3CC4=CC=CC=C41)[H])[C@@H]2C
Biological Activity:
BRL-41992 is a selective α₂B-adrenergic receptor antagonist. BRL-41992 exhibits 94-fold higher selectivity for the α₂B-receptor than for the α₂A-receptor with Kᵢ values in neonatal rat lung tissue (expressing the α₂B-receptor) and in human platelet membranes (expressing the α₂A-receptor) of 1.1 and 103.3 nM. BRL-41992 can be used to verify the functional differences of α₂ receptor subtypes[1][2].
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BRL-41992 | BRL-41992 is a selective α₂B-adrenergic receptor antagonist. BRL-41992 exhibits 94-fold higher selectivity for the α₂B-receptor than for the α₂A-receptor with Kᵢ values in neonatal rat lung tissue (expressing the α₂B-receptor) and in human platelet membranes (expressing the α₂A-receptor) of 1.1 and 103.3 nM. BRL-41992 can be used to verify the functional differences of α₂ receptor subtypes. |
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References
- [1]. Millan MJ. Evidence that an alpha 2A-adrenoceptor subtype mediates antinociception in mice. Eur J Pharmacol. 1992 May 14;215(2-3):355-6. [Content Brief]
- [2]. Young P, et al. Novel α2-adrenoceptor antagonists show selectivity for α2A-and α2B-adrenoceptor subtypes. European journal of pharmacology. 1989 Sep 22;168(3):381-6
