1252037-41-4
Chemical Structure
PrCP-7414
- CAS No.: 1252037-41-4
- Formula:C31H33Cl2N5O2
- Molecular Weight:578.53
InChIKey: PHUWAMRFIHBBMJ-OALGXETFSA-N
SMILES: C[C@@H](C1=CC=C(C2=CC=CC=C2)C=C1)[C@H](NC(C(C)(N)C)=O)C(N3[C@@H](CCC3)C(NC4=C5)=NC4=CC(Cl)=C5Cl)=O
Biological Activity: PrCP-7414 is a prolyl carboxypeptidase (PRCP) inhibitor. PrCP-7414 blocks PRCP-mediated activation of the IGF1R/HER3 signaling pathway and subsequent AKT activation. PrCP-7414 exhibits pro-apoptotic, anti-tumor and synergistic cytotoxic activities, and inhibits the proliferation and survival of triple-negative breast cancer cells. PrCP-7414 can be used for the research of breast cancer[1][2].
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PrCP-7414 | PrCP-7414 is a prolyl carboxypeptidase (PRCP) inhibitor. PrCP-7414 blocks PRCP-mediated activation of the IGF1R/HER3 signaling pathway and subsequent AKT activation. PrCP-7414 exhibits pro-apoptotic, anti-tumor and synergistic cytotoxic activities, and inhibits the proliferation and survival of triple-negative breast cancer cells. PrCP-7414 can be used for the research of breast cancer. | |||||||||||||||||||||
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- [1]. Duan L, et al. Prolylcarboxypeptidase promotes IGF1R/HER3 signaling and is a potential target to improve endocrine therapy response in estrogen receptor positive breast cancer. Cancer Biol Ther. 2022;23(1):1-10. [Content Brief]
- [2]. Duan L, et al. Prolyl Carboxypeptidase Maintains Receptor Tyrosine Kinase Signaling and Is a Potential Therapeutic Target in Triple Negative Breast Cancer. Cancers (Basel). 2022;14(3):739. Published 2022 Jan 31. [Content Brief]
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