1257067-10-9
Chemical Structure
Carboetomidate
- CAS No.: 1257067-10-9
- Formula:C15H17NO2
- Molecular Weight:243.31
IUPAC Name: ethyl (R)-1-(1-phenylethyl)-1H-pyrrole-2-carboxylate
InChIKey: YRYOWTHHYBWOJL-GFCCVEGCSA-N
SMILES: [C@H](C)(N1C(C(OCC)=O)=CC=C1)C2=CC=CC=C2
Biological Activity: Carboetomidate is a pyrrole derivative analogous to the sedative-hypnotic drug Etomidate, which induces general anesthesia while avoiding the inhibition of adrenal steroid synthesis. Carboetomidate enhances GABAA receptor function via β2/β3 subunits, inhibits neuronal nicotinic acetylcholine receptors (nAChR) and 5-HT3A receptors, and increases plasma IL-10 levels during endotoxemia. Carboetomidate is applicable to research related to sepsis and sleep disorders[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Carboetomidate | Carboetomidate is a pyrrole derivative analogous to the sedative-hypnotic drug Etomidate, which induces general anesthesia while avoiding the inhibition of adrenal steroid synthesis. Carboetomidate enhances GABAA receptor function via β2/β3 subunits, inhibits neuronal nicotinic acetylcholine receptors (nAChR) and 5-HT3A receptors, and increases plasma IL-10 levels during endotoxemia. Carboetomidate is applicable to research related to sepsis and sleep disorders. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Shanmugasundararaj S, et al. Carboetomidate: an analog of etomidate that interacts weakly with 11β-hydroxylase. Anesthesia and analgesia. 2013 Jun;116(6):1249-56.
- [2]. Pejo E, et al. Differential effects of etomidate and its pyrrole analogue carboetomidate on the adrenocortical and cytokine responses to endotoxemia. Critical care medicine. 2012 Jan;40(1):187-92.
- [3]. Desai R, et al. The pyrrole etomidate analog carboetomidate potently inhibits human 5-HT3A receptor function: comparisons with etomidate and potential implications for emetogenesis. Anesthesia and analgesia. 2013 Mar;116(3):573-9. [Content Brief]
- [4]. Khurmi N, et al. Pharmacologic Considerations for Pediatric Sedation and Anesthesia Outside the Operating Room: A Review for Anesthesia and Non-Anesthesia Providers. Paediatric drugs. 2017 Oct;19(5):435-446.
- [5]. Cotten JF, et al. Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function. Anesthesiology. 2010 Mar;112(3):637-44.
- [6]. Pierce DW, et al. Carboetomidate inhibits alpha4/beta2 neuronal nicotinic acetylcholine receptors at concentrations affecting animals. Anesthesia and analgesia. 2012 Jul;115(1):70-2.
