1261393-19-4
Chemical Structure
Candesartan Cilexetil-d11
Synonym(s): TCV-116-d11
- CAS No.: 1261393-19-4
- Formula:C33H23D11N6O6
- Molecular Weight:621.73
InChIKey: GHOSNRCGJFBJIB-XLHVCENVSA-N
SMILES: O=C(C1=CC=CC2=C1N(C(OCC)=N2)CC3=CC=C(C=C3)C4=CC=CC=C4C5=NN=NN5)OC(OC(OC6(C([2H])(C([2H])(C([2H])(C([2H])(C6([2H])[2H])[2H])[2H])[2H])[2H])[2H])=O)C
Biological Activity: Candesartan Cilexetil-d11 (TCV-116-d11) is deuterium labeled Candesartan Cilexetil. Candesartan Cilexetil (TCV-116) is an angiotensin II receptor inhibitor. Candesartan Cilexetil ameliorates the pulmonary fibrosis and has antiviral and skin wound healing effect. Candesartan Cilexetil can be used for the research of high blood pressure[1][2][3][4][5][6].
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Candesartan Cilexetil-d11 | Candesartan Cilexetil-d11 (TCV-116-d11) is deuterium labeled Candesartan Cilexetil. Candesartan Cilexetil (TCV-116) is an angiotensin II receptor inhibitor. Candesartan Cilexetil ameliorates the pulmonary fibrosis and has antiviral and skin wound healing effect. Candesartan Cilexetil can be used for the research of high blood pressure. | |||||||||||||||||||||
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Candesartan Cilexetil (Standard) | 99.56% | Candesartan Cilexetil (Standard) is the analytical standard of Candesartan Cilexetil. This product is intended for research and analytical applications. Candesartan Cilexetil (TCV-116) is an angiotensin II receptor inhibitor. Candesartan Cilexetil ameliorates the pulmonary fibrosis and has antiviral and skin wound healing effect. Candesartan Cilexetil can be used for the research of high blood pressure. | ||||||||||||||||||||
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Candesartan Cilexetil | 99.66% | Candesartan Cilexetil (TCV-116) is an angiotensin II receptor inhibitor. Candesartan Cilexetil ameliorates the pulmonary fibrosis and has antiviral and skin wound healing effect. Candesartan Cilexetil can be used for the research of high blood pressure. | ||||||||||||||||||||
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- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Loe M W C, et al. Antiviral activity of the FDA-approved drug candesartan cilexetil against Zika virus infection [J]. Antiviral Research, 2019, 172: 104637. [Content Brief]
- [3]. Kobayashi N, et al. Effects of TCV-116 on expression of NOS and adrenomedullin in failing heart of Dahl salt-sensitive rats [J]. Atherosclerosis, 2001, 156(2): 255-265. [Content Brief]
- [4]. Takeda H, et al. Effects of angiotensin II receptor signaling during skin wound healing [J]. The American journal of pathology, 2004, 165(5): 1653-1662. [Content Brief]
- [5]. McClellan K J, et al. Candesartan cilexetil: a review of its use in essential hypertension [J]. Drugs, 1998, 56: 847-869. [Content Brief]
- [6]. Kojima M, et al. Angiotensin II receptor antagonist TCV-116 induces regression of hypertensive left ventricular hypertrophy in vivo and inhibits the intracellular signaling pathway of stretch-mediated cardiomyocyte hypertrophy in vitro [J]. Circulation, 1994, 89(5): 2204-2211. [Content Brief]
