1276197-21-7
Chemical Structure
Flecainide-d4 acetate
Synonym(s): R-818-d4
- CAS No.: 1276197-21-7
- Formula:C19H20D4F6N2O5
- Molecular Weight:478.42
IUPAC Name: N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy-1,1-d2)benzamide acetate
InChIKey: RKXNZRPQSOPPRN-PQDNHERISA-N
SMILES: CC(O)=O.O=C(C1=C(C=CC(OC([2H])([2H])C(F)(F)F)=C1)OC([2H])([2H])C(F)(F)F)NCC2CCCCN2
Biological Activity: Flecainide-d4 (acetate) is the deuterium labeled Flecainide acetate. Flecainide acetate (R-818) is a class 1C antiarrhythmic agent especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential[1][2].
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Flecainide-d4 acetate | 99.72% | Flecainide-d4 (acetate) is the deuterium labeled Flecainide acetate. Flecainide acetate (R-818) is a class 1C antiarrhythmic agent especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential. | ||||||||||||||||||||
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Flecainide acetate (Standard) | ≥98% | Flecainide (acetate) (Standard) is the analytical standard of Flecainide (acetate). This product is intended for research and analytical applications. Flecainide acetate (R-818) is a class 1C antiarrhythmic agent especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential. | ||||||||||||||||||||
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Flecainide acetate | 99.35% | Flecainide acetate (R-818) is a class 1C antiarrhythmic agent especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential. | ||||||||||||||||||||
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- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Yamashita T, Nakajima T, Hamada E, Flecainide inhibits the transient outward current in atrial myocytes isolated from the rabbit heart. J Pharmacol Exp Ther. 1995 Jul;274(1):315-21. [Content Brief]
