128826-89-1
128826-89-1
Chemical Structure
Salbostatin
- CAS No.: 128826-89-1
- Formula:C13H23NO8
- Molecular Weight:321.32
InChIKey: OCTNNXHKAOLDJL-BMGYQPLYSA-N
SMILES: O[C@H]1[C@H](O)C(CO)=C[C@H](N[C@H]2CO[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H]1O
Biological Activity: Salbostatin is a competitive Trehalase inhibitor, with an IC50 of 8.3 μM against silkworm trehalase and a Ki of 180 nM against porcine trehalase. Salbostatin is isolated from Streptomyces albus. Salbostatin shows no antibacterial activity, and does not inhibit porcine intestinal mucosa sucrase (EC 3.2.1.26) or maltase (EC 3.2.1.20). Salbostatin can be used in studies related to the development of plant protectants[1][2].
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Salbostatin | Salbostatin is a competitive Trehalase inhibitor, with an IC50 of 8.3 μM against silkworm trehalase and a Ki of 180 nM against porcine trehalase. Salbostatin is isolated from Streptomyces albus. Salbostatin shows no antibacterial activity, and does not inhibit porcine intestinal mucosa sucrase (EC 3.2.1.26) or maltase (EC 3.2.1.20). Salbostatin can be used in studies related to the development of plant protectants. | |||||||||||||||||||||
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References
- [1]. Yamagishi T, et al. Total synthesis of the trehalase inhibitor salbostatin[J]. Chemistry–A European Journal, 1995, 1(9): 634-636.
- [2]. Vértesy L, et al. The trehalase inhibitor salbostatin, a novel metabolite from Streptomyces albus, ATCC21838[J]. Angewandte Chemie International Edition in English, 1994, 33(18): 1844-1846.
