129981-36-8
Chemical Structure
Sampatrilat
Synonym(s): UK-81252
- CAS No.: 129981-36-8
- Formula:C26H40N4O9S
- Molecular Weight:584.68
IUPAC Name: (S)-3-((S)-6-amino-2-(methylsulfonamido)hexanamido)-2-((1-(((S)-1-carboxy-2-(4-hydroxyphenyl)ethyl)carbamoyl)cyclopentyl)methyl)propanoic acid
InChIKey: LPUDGHQMOAHMMF-JBACZVJFSA-N
SMILES: OC([C@H](CNC([C@@H](NS(C)(=O)=O)CCCCN)=O)CC1(CCCC1)C(N[C@H](C(O)=O)CC2=CC=C(O)C=C2)=O)=O
Biological Activity: Sampatrilat (UK-81252) is a potent and orally active vasopeptidase inhibitor of ACE and neutral endopeptidase (NEP). Sampatrilat inhibits C-domain ACE (Ki=13.8 nM) 12.4-fold more potent than that for the N-domain (Ki=171.9 nM). Sampatrilat (UK-81252) can be used for the study of chronic heart failure and blood pressure regulation[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Sampatrilat | 99.22% | Sampatrilat (UK-81252) is a potent and orally active vasopeptidase inhibitor of ACE and neutral endopeptidase (NEP). Sampatrilat inhibits C-domain ACE (Ki=13.8 nM) 12.4-fold more potent than that for the N-domain (Ki=171.9 nM). Sampatrilat (UK-81252) can be used for the study of chronic heart failure and blood pressure regulation. | ||||||||||||||||||||
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- [1]. Sharma RK, et al. The Dynamic Nonprime Binding of Sampatrilat to the C-Domain of Angiotensin-Converting Enzyme. J Chem Inf Model. 2016 Dec 27;56(12):2486-2494. [Content Brief]
- [2]. Maki T, et al. Beneficial effects of sampatrilat, a novel vasopeptidase inhibitor, on cardiac remodeling and function of rats with chronic heart failure following left coronary artery ligation.J Pharmacol Exp Ther. 2003 Apr;305(1):97-105. [Content Brief]
Keywords
