130603-71-3
Chemical Structure
α-Glucosylrutin
- CAS No.: 130603-71-3
- Formula:C33H40O21
- Molecular Weight:772.66
InChIKey: PFPQMWRASYNLMZ-LGIMBNBCSA-N
SMILES: O=C(C(O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO)CO[C@H]3[C@@H]([C@@H]([C@H]([C@@H](O3)C)O)O)O)=C(C4=CC(O)=C(C=C4)O)OC5=CC(O)=C6)C5=C6O
Biological Activity: α-Glucosylrutin, a flavonoid, is a potent antioxidant with free radical scavenging activity. α-Glucosylrutin reduces MMP-1 gene expression, protein expression, and enzyme activity, and reduces MMP-2 protein expression and enzyme activity in UVA-irradiated human dermal fibroblasts. α-Glucosylrutin prevents oxidative stress-induced intracellular tyrosine residue phosphorylation and counteracts intracellular thiol level depletion in human skin cells. α-Glucosylrutin is effective in the prevention of dermatologic diseases in which oxidative stress is of pathogenetic relevance, e.g. in polymorphous light eruption (PLE). α-Glucosylrutin can be used for the research of UV-induced skin photodamage/photoaging[1][2].
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α-Glucosylrutin | 96.32% | α-Glucosylrutin, a flavonoid, is a potent antioxidant with free radical scavenging activity. α-Glucosylrutin reduces MMP-1 gene expression, protein expression, and enzyme activity, and reduces MMP-2 protein expression and enzyme activity in UVA-irradiated human dermal fibroblasts. α-Glucosylrutin prevents oxidative stress-induced intracellular tyrosine residue phosphorylation and counteracts intracellular thiol level depletion in human skin cells. α-Glucosylrutin is effective in the prevention of dermatologic diseases in which oxidative stress is of pathogenetic relevance, e.g. in polymorphous light eruption (PLE). α-Glucosylrutin can be used for the research of UV-induced skin photodamage/photoaging. | ||||||||||||||||||||
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- [1]. Hantke B, et al. Influence of flavonoids and vitamins on the MMP- and TIMP-expression of human dermal fibroblasts after UVA irradiation. Photochem Photobiol Sci. 2002;1(10):826-833. [Content Brief]
- [2]. Wolber R, et al. Alpha-Glucosylrutin: ein hochwirksames Flavonoid zum Schutz vor oxidativem Stress [Alpha-glucosylrutin, a highly effective flavonoid for protection against oxidative stress]. J Dtsch Dermatol Ges. 2004 Jul;2(7):580-7. [Content Brief]
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