α-Glucosylrutin
Based on 1 Customer Validation
α-Glucosylrutin, a flavonoid, is a potent antioxidant with free radical scavenging activity. α-Glucosylrutin reduces MMP-1 gene expression, protein expression, and enzyme activity, and reduces MMP-2 protein expression and enzyme activity in UVA-irradiated human dermal fibroblasts. α-Glucosylrutin prevents oxidative stress-induced intracellular tyrosine residue phosphorylation and counteracts intracellular thiol level depletion in human skin cells. α-Glucosylrutin is effective in the prevention of dermatologic diseases in which oxidative stress is of pathogenetic relevance, e.g. in polymorphous light eruption (PLE). α-Glucosylrutin can be used for the research of UV-induced skin photodamage/photoaging.
For research use only. We do not sell to patients.
- Purity: 96.32%
- CAS No.: 130603-71-3
- Formula: C33H40O21
- Molecular Weight:772.66
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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MMP-1 |
MMP-2 |
α-Glucosylrutin (150 μM; 24 h pre-incubation) potently reduces UVA-induced MMP-1, total MMP-2, and active MMP-2 protein expression in human dermal fibroblasts from the shoulder in monolayer culture, without altering TIMP levels[1].
α-Glucosylrutin (150 μM; 24 h pre-incubation) potently reduces UVA-induced MMP-1, total MMP-2, and active MMP-2 protein expression in human dermal fibroblasts from the shoulder in collagen gel culture, without altering TIMP levels[1].
α-Glucosylrutin (150 μM; 24 h pre-incubation) reduces UVA-induced MMP-1 and active MMP-2 protein expression in human dermal fibroblasts from the upper eyelid in collagen gel culture, without altering TIMP levels[1].
α-Glucosylrutin (0.05%) preserves thiol levels and protects human skin cells against H2O2-induced oxidative stress[2].
α-Glucosylrutin (0.25%; 30 min) protects human skin cells against UV-induced photodamage[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 130603-71-3
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Appearance Solid
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Molecular Weight 772.66
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Formula C33H40O21
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Color Light yellow to yellow
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SMILES
O=C(C(O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO)CO[C@H]3[C@@H]([C@@H]([C@H]([C@@H](O3)C)O)O)O)=C(C4=CC(O)=C(C=C4)O)OC5=CC(O)=C6)C5=C6O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : ≥ 200 mg/mL (258.85 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (284 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Hantke B, et al. Influence of flavonoids and vitamins on the MMP- and TIMP-expression of human dermal fibroblasts after UVA irradiation. Photochem Photobiol Sci. 2002;1(10):826-833. [Content Brief]
[2]. Wolber R, et al. Alpha-Glucosylrutin: ein hochwirksames Flavonoid zum Schutz vor oxidativem Stress [Alpha-glucosylrutin, a highly effective flavonoid for protection against oxidative stress]. J Dtsch Dermatol Ges. 2004 Jul;2(7):580-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.2942 mL | 6.4712 mL | 12.9423 mL | 32.3558 mL |
| 5 mM | 0.2588 mL | 1.2942 mL | 2.5885 mL | 6.4712 mL | |
| 10 mM | 0.1294 mL | 0.6471 mL | 1.2942 mL | 3.2356 mL | |
| 15 mM | 0.0863 mL | 0.4314 mL | 0.8628 mL | 2.1571 mL | |
| 20 mM | 0.0647 mL | 0.3236 mL | 0.6471 mL | 1.6178 mL | |
| 25 mM | 0.0518 mL | 0.2588 mL | 0.5177 mL | 1.2942 mL | |
| 30 mM | 0.0431 mL | 0.2157 mL | 0.4314 mL | 1.0785 mL | |
| 40 mM | 0.0324 mL | 0.1618 mL | 0.3236 mL | 0.8089 mL | |
| 50 mM | 0.0259 mL | 0.1294 mL | 0.2588 mL | 0.6471 mL | |
| 60 mM | 0.0216 mL | 0.1079 mL | 0.2157 mL | 0.5393 mL | |
| 80 mM | 0.0162 mL | 0.0809 mL | 0.1618 mL | 0.4044 mL | |
| 100 mM | 0.0129 mL | 0.0647 mL | 0.1294 mL | 0.3236 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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