132210-43-6
132210-43-6
Chemical Structure
Cipamfylline
- CAS No.: 132210-43-6
- Formula:C13H17N5O2
- Molecular Weight:275.31
IUPAC Name: 8-amino-1,3-bis(cyclopropylmethyl)-3,9-dihydro-1H-purine-2,6-dione
InChIKey: KSPYMJJKQMWWNB-UHFFFAOYSA-N
SMILES: O=C(N1CC2CC2)N(CC3CC3)C4=C(N=C(N)N4)C1=O
Biological Activity: Cipamfylline is a PDE4 inhibitor that can cause PDE4A4 to accumulate in specific areas of the cell through interaction with the ubiquitin scaffolding protein p62. Cipamfylline can be used in the research of atopic dermatitis[1][2].
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Cipamfylline | Cipamfylline is a PDE4 inhibitor that can cause PDE4A4 to accumulate in specific areas of the cell through interaction with the ubiquitin scaffolding protein p62. Cipamfylline can be used in the research of atopic dermatitis. | |||||||||||||||||||||
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References
- [1]. Griffiths CE, et al. Randomized comparison of the type 4 phosphodiesterase inhibitor cipamfylline cream, cream vehicle and hydrocortisone 17-butyrate cream for the treatment of atopic dermatitis. Br J Dermatol. 2002 Aug;147(2):299-307. [Content Brief]
- [2]. Day JP, et al. Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4). J Med Chem. 2011 May 12;54(9):3331-47. [Content Brief]
Keywords
