133920-70-4
Chemical Structure
FK960
- CAS No.: 133920-70-4
- Formula:C13H16FN3O2
- Molecular Weight:265.28
IUPAC Name: N-(4-acetylpiperazin-1-yl)-4-fluorobenzamide
InChIKey: XTOKQKWTUYYVAO-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C=C1)F)NN2CCN(CC2)C(C)=O
Biological Activity: FK960 is a potential anti-dementia agent that reverses the reduction in cerebral blood flow (rCBF) caused by sensory stimulation by enhancing cholinergic neurotransmission. In macaque experiments, physostigmine (AChE inhibitor; HY-N6608) was able to completely eliminate the rCBF in the sensory cortex increased by vibrotactile stimulation. FK960 (1-1000 μg/kg) can restore the eliminated rCBF response, and the action time can last for 1 hour. However, FK960 cannot restore the rCBF response eliminated by HA-966 (NMDA modulator; HY-100822), indicating that its function is not dependent on non-glutamatergic neurotransmission.
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FK960 | FK960 is a potential anti-dementia agent that reverses the reduction in cerebral blood flow (rCBF) caused by sensory stimulation by enhancing cholinergic neurotransmission. In macaque experiments, physostigmine (AChE inhibitor; HY-N6608) was able to completely eliminate the rCBF in the sensory cortex increased by vibrotactile stimulation. FK960 (1-1000 μg/kg) can restore the eliminated rCBF response, and the action time can last for 1 hour. However, FK960 cannot restore the rCBF response eliminated by HA-966 (NMDA modulator; HY-100822), indicating that its function is not dependent on non-glutamatergic neurotransmission. | |||||||||||||||||||||
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Keywords
