134377-69-8
134377-69-8
Chemical Structure
Safironil
- CAS No.: 134377-69-8
- Formula:C15H23N3O4
- Molecular Weight:309.36
IUPAC Name: N2,N4-bis(3-methoxypropyl)pyridine-2,4-dicarboxamide
InChIKey: HLSXICGBWKECLM-UHFFFAOYSA-N
SMILES: O=C(NCCCOC)C1=NC=CC(C(NCCCOC)=O)=C1
Biological Activity: Safironil is an antifibrotic compound. Safironil is a competitive inhibitor of collagen protein synthesis. Safironil reduces liver fibrogenesis by inhibiting HSC activation[1][2].
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Safironil | Safironil is an antifibrotic compound. Safironil is a competitive inhibitor of collagen protein synthesis. Safironil reduces liver fibrogenesis by inhibiting HSC activation. | |||||||||||||||||||||
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References
- [1]. NO Al-Harbi, et al. Reversal of Liver Fibrosis in Chronic Murine Schistosomiasis mansoni by Safironil/Praziquantel. Tropical Journal of Pharmaceutical Research. Vol. 11 No. 4 (2012)
- [2]. Wang YJ, et al. Two novel antifibrotics, HOE 077 and Safironil, modulate stellate cell activation in rat liver injury: differential effects in males and females. Am J Pathol. 1998 Jan;152(1):279-87. [Content Brief]
Keywords
