1357171-62-0
1357171-62-0
Chemical Structure
ML228
Synonym(s): CID-46742353
- CAS No.: 1357171-62-0
- Formula:C27H21N5
- Molecular Weight:415.49
IUPAC Name: N-([1,1'-biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine
InChIKey: QNRODODTMXCRKU-UHFFFAOYSA-N
SMILES: C1(C2=NC=CC=C2)=NC(NCC3=CC=C(C4=CC=CC=C4)C=C3)=C(C5=CC=CC=C5)N=N1
Biological Activity: ML228 (CID-46742353) is a potent the Hypoxia Inducible Factor (HIF) pathway activator with EC50 of 1 μM. ML228 potently activates HIF in vitro as well as its downstream target VEGF[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ML228 | 98.0% | ML228 (CID-46742353) is a potent the Hypoxia Inducible Factor (HIF) pathway activator with EC50 of 1 μM. ML228 potently activates HIF in vitro as well as its downstream target VEGF. | ||||||||||||||||||||
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References
- [1]. Theriault JR, et al. Discovery of a Small Molecule Activator of the Hypoxia Inducible Factor Pathway. Probe Reports from the NIH Molecular Libraries Program. [Content Brief]
- [2]. Theriault JR, et al. Discovery of a new molecular probe ML228: an activator of the hypoxia inducible factor (HIF) pathway. Bioorg Med Chem Lett. 2012 Jan 1;22(1):76-81. [Content Brief]
Keywords
