1358575-02-6
1358575-02-6
Chemical Structure
TP-024
Synonym(s): FTBMT
- CAS No.: 1358575-02-6
- Formula:C19H16F4N4O
- Molecular Weight:392.35
IUPAC Name: 4-(3-(3-fluoro-5-(trifluoromethyl)benzyl)-5-methyl-1H-1,2,4-triazol-1-yl)-2-methylbenzamide
InChIKey: TYXSIXOYTBHZFA-UHFFFAOYSA-N
SMILES: O=C(N)C1=CC=C(N2C(C)=NC(CC3=CC(C(F)(F)F)=CC(F)=C3)=N2)C=C1C
Biological Activity: TP-024 (FTBMT), a chemical probe, is a selective GPR52 agonist with an EC50 of 75 nM[1]. TP-024 has antipsychotic and procognitive properties[2].
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TP-024 | 99.41% | TP-024 (FTBMT), a chemical probe, is a selective GPR52 agonist with an EC50 of 75 nM. TP-024 has antipsychotic and procognitive properties. | ||||||||||||||||||||
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TP-024 (Standard) | ≥98% | TP-024 (Standard) (FTBMT (Standard)) is the analytical standard of TP-024 (HY-101787). This product is intended for research and analytical applications. TP-024 (FTBMT), a chemical probe, is a selective GPR52 agonist with an EC50 of 75 nM. TP-024 has antipsychotic and procognitive properties. | ||||||||||||||||||||
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References
- [1]. Tokumaru K, et al. Design, synthesis, and pharmacological evaluation of 4-azolyl-benzamide derivatives as novel GPR52 agonists. Bioorg Med Chem. 2017 Jun 15;25(12):3098-3115. [Content Brief]
- [2]. Nishiyama K, et al. FTBMT, a Novel and Selective GPR52 Agonist, Demonstrates Antipsychotic-Like and Procognitive Effects in Rodents, Revealing a Potential Therapeutic Agent for Schizophrenia. J Pharmacol Exp Ther. 2017 Nov;363(2):253-264. [Content Brief]
