1398112-33-8
1398112-33-8
Chemical Structure
(S)-Verapamil-d3 (hydrochloride)
Synonym(s): (S)-(-)-Verapamil-d3 (hydrochloride)
- CAS No.: 1398112-33-8
- Formula:C27H36D3ClN2O4
- Molecular Weight:494.08
IUPAC Name: (S)-5-((3,4-dimethoxyphenethyl)(methyl-d3)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile hydrochloride
InChIKey: DOQPXTMNIUCOSY-OVEJCBMJSA-N
SMILES: COC(C=C1CCN(C([2H])([2H])[2H])CCC[C@@](C#N)(C2=CC(OC)=C(C=C2)OC)C(C)C)=C(C=C1)OC.Cl
Biological Activity: (S)-(-)-Verapamil-d3 (hydrochloride) is the deuterium labeled (S)-(-)-Verapamil hydrochloride[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(S)-Verapamil-d3 (hydrochloride) | (S)-(-)-Verapamil-d3 (hydrochloride) is the deuterium labeled (S)-(-)-Verapamil hydrochloride. | |||||||||||||||||||||
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(S)-Verapamil-d6 (hydrochloride) | (S)-Verapamil-d6 ((S)-(-)-Verapamil-d6) hydrochloride is the deuterium labeled (S)-Verapamil hydrochloride. (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells. | |||||||||||||||||||||
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(S)-Verapamil | (S)-Verapamil ((S)-(-)-Verapamil) is an orally active MRP1 (ABCC1) modulator with a Kd value of 113 nM for hamster MRP1. (S)-Verapamil regulates MRP1, promotes MRP1-mediated glutathione efflux and the transport of calcein and leukotriene C4, reverses glutathione-activated MRP1 ATPase activity, and ultimately depletes intracellular glutathione and induces cell death. (S)-Verapamil specifically induces apoptosis in MRP1-overexpressing tumor cells. (S)-Verapamil can be used in research related to cancer, cardiac diseases such as supraventricular arrhythmia, and hypertension. | |||||||||||||||||||||
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References
