1410738-11-2
Chemical Structure
MI-2103
- CAS No.: 1410738-11-2
- Formula:C24H24Cl2FN3O2
- Molecular Weight:476.37
IUPAC Name: (3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-N-methyl-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide
InChIKey: LHBZDASUSDFFIL-MFSJNOQSSA-N
SMILES: O=C([C@H](N1)[C@H](C2=CC=CC(Cl)=C2F)[C@]3(C(NC4=C3C=CC(Cl)=C4)=O)C51CCCCC5)NC
Biological Activity: MI-2103 is a MDM2 inhibitor with an IC50 of 48.1 nM. MI-2103 inhibits the growth of leukemia and breast cancer cells; it exerts no growth-inhibitory effect on cancer cells with p53 mutation or deletion. MI-2103 serves as a target protein ligand for the synthesis of MG-277 (HY-130122). MI-2103 is applicable to the research of leukemia and breast cancer[1].
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MI-2103 | MI-2103 is a MDM2 inhibitor with an IC50 of 48.1 nM. MI-2103 inhibits the growth of leukemia and breast cancer cells; it exerts no growth-inhibitory effect on cancer cells with p53 mutation or deletion. MI-2103 serves as a target protein ligand for the synthesis of MG-277 (HY-130122). MI-2103 is applicable to the research of leukemia and breast cancer. | |||||||||||||||||||||
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Keywords
