1422526-93-9
1422526-93-9
Chemical Structure
Biological Activity: CR-8020 is a broadly neutralizing antibody targeting the stem region of influenza A virus hemagglutinin (HA), with IC50 values of 0.06 nM or 3.36 nM. CR-8020 mediates antibody-dependent cellular cytotoxicity by activating Fcγ receptors. CR-8020 blocks viral fusion and entry. CR-8020 protects mice from lethal influenza A virus challenge. CR-8020 can be used in research related to influenza A virus infections (H3N2 and H7N9)[1][2].
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CR-8020 | 95% | CR-8020 is a broadly neutralizing antibody targeting the stem region of influenza A virus hemagglutinin (HA), with IC50 values of 0.06 nM or 3.36 nM. CR-8020 mediates antibody-dependent cellular cytotoxicity by activating Fcγ receptors. CR-8020 blocks viral fusion and entry. CR-8020 protects mice from lethal influenza A virus challenge. CR-8020 can be used in research related to influenza A virus infections (H3N2 and H7N9). | ||||||||||||||||||||
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References
- [1]. Tharakaraman K, et al. Broadly neutralizing influenza hemagglutinin stem-specific antibody CR8020 targets residues that are prone to escape due to host selection pressure. Cell host & microbe. 2014 May 14;15(5):644-51. [Content Brief]
- [2]. Zeng LY, et al. Investigational hemagglutinin-targeted influenza virus inhibitors. Expert opinion on investigational drugs. 2017 Jan;26(1):63-73. [Content Brief]
Keywords
