1426824-36-3
1426824-36-3
Chemical Structure
BPH-1218
- CAS 番号: 1426824-36-3
- Formula:C15H30N2O6P2
- Molecular Weight:396.36
IUPAC Name: hydrogen (2-(1-decyl-1H-imidazol-3-ium-3-yl)-1-phosphonoethyl)phosphonate
InChIKey: GYTSEUQBLYSXFG-UHFFFAOYSA-N
SMILES: O=P(O)(C(P(O)(O)=O)C[N+]1=CN(CCCCCCCCCC)C=C1)[O-]
Biological Activity: BPH-1218 is an inhibitor of squalene synthase (SQS), with the IC50 of 31 nM and 64 nM for TcSQS and HsSQS, respectively, that can be used as an anti-infective agent[1][2][3].
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BPH-1218 | BPH-1218 is an inhibitor of squalene synthase (SQS), with the IC50 of 31 nM and 64 nM for TcSQS and HsSQS, respectively, that can be used as an anti-infective agent. | |||||||||||||||||||||
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References
- [1]. Melissa A Sleda, wt al. The Heptaprenyl Diphosphate Synthase (Coq1) Is the Target of a Lipophilic Bisphosphonate That Protects Mice against Toxoplasma gondii Infection. mBio. 2022 Oct 26;13(5):e0196622. [Content Brief]
- [2]. M J Barry, et al. Benign Prostatic Hyperplasia Specific Health Status Measures in Clinical Research: How Much Change in the American Urological Association Symptom Index and the Benign Prostatic Hyperplasia Impact Index is Perceptible to Patients? J Urol. 1995 Nov;154(5):1770-4. [Content Brief]
- [3]. Na Shang, et al. Squalene Synthase As a Target for Chagas Disease Therapeutics. PLoS Pathog. 2014 May 1;10(5):e1004114. [Content Brief]
