1429505-03-2
1429505-03-2
Chemical Structure
Soticlestat
Synonym(s): TAK-935; OV935
- CAS No.: 1429505-03-2
- Formula:C23H23N3O2
- Molecular Weight:373.45
IUPAC Name: [2,4'-bipyridin]-3-yl(4-benzyl-4-hydroxypiperidin-1-yl)methanone
InChIKey: XKUZMIUSBMCVPP-UHFFFAOYSA-N
SMILES: O=C(N1CCC(CC2=CC=CC=C2)(O)CC1)C3=C(C4=CC=NC=C4)N=CC=C3
Biological Activity: Soticlestat (TAK-935; OV935) is a first-in-class, potent, selective, and orally active cholesterol 24-hydroxylase (CH24H) inhibitor. Soticlestat has the potential for epilepsy syndromes research[1][2].
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Soticlestat | 99.83% | Soticlestat (TAK-935; OV935) is a first-in-class, potent, selective, and orally active cholesterol 24-hydroxylase (CH24H) inhibitor. Soticlestat has the potential for epilepsy syndromes research. | ||||||||||||||||||||
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Soticlestat (Standard) | ≥98% | Soticlestat (Standard) is the analytical standard of Soticlestat (HY-109123). This product is intended for research and analytical applications. Soticlestat (TAK-935; OV935) is a first-in-class, potent, selective, and orally active cholesterol 24-hydroxylase (CH24H) inhibitor. Soticlestat has the potential for epilepsy syndromes research. | ||||||||||||||||||||
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References
- [1]. Toshiya Nishi, et al. Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice. Sci Rep. 2020 Oct 13;10(1):17081. [Content Brief]
- [2]. Krista Eschbach, et al. Stiripentol for the treatment of seizures in Dravet syndrome. Expert Rev Clin Pharmacol. 2019 May;12(5):379-388. [Content Brief]
Keywords
