1431362-34-3
1431362-34-3
Chemical Structure
Ac-PKM-AMC
- CAS No.: 1431362-34-3
- Formula:C28H39N5O6S
- Molecular Weight:573.70
InChIKey: BRKUJTABTYBZIF-VABKMULXSA-N
SMILES: CC(C1=CC=C2NC([C@H](CCSC)NC([C@H](CCCCN)NC([C@H]3N(C(C)=O)CCC3)=O)=O)=O)=CC(OC1=C2)=O
Biological Activity: Ac-PKM-AMC is a fluorescent tripeptide substrate for ClpP1P2 peptidase (excitation and emission: 380/460 nm). Ac-PKM-AMC is used to measure Mtb ClpP1P2 peptidase activity[1][2][3].
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Ac-PKM-AMC | Ac-PKM-AMC is a fluorescent tripeptide substrate for ClpP1P2 peptidase (excitation and emission: 380/460 nm). Ac-PKM-AMC is used to measure Mtb ClpP1P2 peptidase activity. | |||||||||||||||||||||
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References
- [1]. Xiao G, et al. Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria. mLife. 2025 Apr;4(2):155-168. [Content Brief]
- [2]. Li M, et al. Structure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, from Mycobacterium tuberculosis. The Journal of biological chemistry. 2016 Apr 01;291(14):7465-76.
- [3]. Akopian T, et al. Cleavage Specificity of Mycobacterium tuberculosis ClpP1P2 Protease and Identification of Novel Peptide Substrates and Boronate Inhibitors with Anti-bacterial Activity. The Journal of biological chemistry. 2015 Apr 24;290(17):11008-20.
