143162-65-6
Chemical Structure
SG-210
Synonym(s): SPR 210
- CAS No.: 143162-65-6
- Formula:C18H11F3N2O3S2
- Molecular Weight:424.42
IUPAC Name: 2-(3-oxo-4-((4,5,7-trifluorobenzo[d]thiazol-2-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]thiazin-2-yl)acetic acid
InChIKey: BUYWFAJWTSIACV-UHFFFAOYSA-N
SMILES: O=C1N(CC2=NC3=C(S2)C(F)=CC(F)=C3F)C4=CC=CC=C4SC1CC(O)=O
Biological Activity: SG-210 (SPR 210) is an orally active and selective aldose reductase (AR) inhibitor. SG-210 has IC50 values of 9.5 nM and 10 nM for AR from porcine lens and human placenta, respectively. SG-210 can inhibit sorbitol accumulation and ameliorate diabetic neuropathy and retinopathy in Streptozotocin (HY-13753)-induced diabetic rats. SG-210 can be used in the research of diseases such as diabetes-related complications[1].
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SG-210 | SG-210 (SPR 210) is an orally active and selective aldose reductase (AR) inhibitor. SG-210 has IC50 values of 9.5 nM and 10 nM for AR from porcine lens and human placenta, respectively. SG-210 can inhibit sorbitol accumulation and ameliorate diabetic neuropathy and retinopathy in Streptozotocin (HY-13753)-induced diabetic rats. SG-210 can be used in the research of diseases such as diabetes-related complications. | |||||||||||||||||||||
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Keywords
