1433361-02-4
Chemical Structure
Vicasinabin
Synonym(s): RG7774
- CAS No.: 1433361-02-4
- Formula:C15H22N10O
- Molecular Weight:358.40
IUPAC Name: (S)-1-(5-(tert-butyl)-3-((1-methyl-1H-tetrazol-5-yl)methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)pyrrolidin-3-ol
InChIKey: MAYZWDRUFKUGGP-VIFPVBQESA-N
SMILES: CC(C)(C)C1=NC(N2CC[C@@H](C2)O)=C(N=N3)C(N3CC4=NN=NN4C)=N1
Biological Activity: Vicasinabin (RG7774) is an orally active, selective, and full CB2R agonist, with EC50 values of 2.81 nM and 2.60 nM for human CB2R and mouse CB2R, respectively. Vicasinabin inhibits inflammation, reduces leukocyte adhesion and decreases vascular permeability by selectively activating CB2R. Vicasinabin can be used in the researches for diabetic retinopathy, uveitis and laser-induced choroidal neovascularization[1][2].
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Vicasinabin | 98.32% | Vicasinabin (RG7774) is an orally active, selective, and full CB2R agonist, with EC50 values of 2.81 nM and 2.60 nM for human CB2R and mouse CB2R, respectively. Vicasinabin inhibits inflammation, reduces leukocyte adhesion and decreases vascular permeability by selectively activating CB2R. Vicasinabin can be used in the researches for diabetic retinopathy, uveitis and laser-induced choroidal neovascularization. | ||||||||||||||||||||
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- [1]. Jean-Michel Adam, et al. Novel [1,2,3]triazolo[4,5-d]pyrimidine derivatives. Patent US20130116236A1.
- [2]. Grether U, et al. RG7774 (Vicasinabin), an orally bioavailable cannabinoid receptor 2 (CB2R) agonist, decreases retinal vascular permeability, leukocyte adhesion, and ocular inflammation in animal models. Front Pharmacol. 2024 Jul 12;15:1426446. [Content Brief]
Keywords
