15301-93-6
15301-93-6
Chemical Structure
Tofenacin
Synonym(s): TOF
- CAS No.: 15301-93-6
- Formula:C17H21NO
- Molecular Weight:255.35
InChIKey: PNYKGCPSFKLFKA-UHFFFAOYSA-N
SMILES: CNCCOC(C1=C(C)C=CC=C1)C2=CC=CC=C2
Biological Activity: Tofenacin (TOF) is an orally active weak anticholinergic compound. Tofenacin can be used to study extrapyramidal symptoms and depressive side effects associated with the use of Fluphenazine decanoate (HY-B1904) [1][2][3][4].
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Tofenacin | Tofenacin (TOF) is an orally active weak anticholinergic compound. Tofenacin can be used to study extrapyramidal symptoms and depressive side effects associated with the use of Fluphenazine decanoate (HY-B1904) . | |||||||||||||||||||||
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References
- [1]. Altamura AC, e al. Residual neuroleptic-induced parkinsonian symptoms in schizophrenia. A naturalistic study with orphenadrine. Pharmacopsychiatry. 1989 Nov;22(6):246-9.
- [2]. Capstick N, et al. A comparative trial of orphenadrine and tofenacin in the control of depression and extrapyramidal side-effects associated with fluphenazine decanoate therapy. The Journal of international medical research. 1976;4(6):435-40.
- [3]. Hespe W, et al. Aspects of the biliary excretion of orphenadrine and its N‑demethylated derivative, tofenacin, in the rat. Eur J Pharmacol. 1970 Dec;13(1):113‑122.
- [4]. Mason ST, et al. Chronic and acute administration of typical and atypical antidepressants on activity of brain noradrenaline systems in the rat thiopentone anaesthesia model. Psychopharmacology. 1984;84(3):304-9.
