1541762-55-3
1541762-55-3
Chemical Structure
Q8
- CAS No.: 1541762-55-3
- Formula:C17H14ClNO2
- Molecular Weight:299.75
IUPAC Name: (E)-2-(2-(quinolin-2-yl)vinyl)benzene-1,4-diol hydrochloride
InChIKey: LNPCQDLAMXHIFY-WVLIHFOGSA-N
SMILES: OC1=CC=C(O)C=C1/C=C/C2=NC3=CC=CC=C3C=C2.Cl
Biological Activity: Q8, an effective antiangiogenic drug, is a CysLt1 antagonist (IC50 of 4.9 μM). Q8 is sufficient to reduce cellular levels of NF-κB and calpain-2 and secreted levels of the proangiogenic proteins intercellular adhesion molecule-1, vascular cell adhesion protein-1, and VEGF[1].
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Q8 | Q8, an effective antiangiogenic drug, is a CysLt1 antagonist (IC50 of 4.9 μM). Q8 is sufficient to reduce cellular levels of NF-κB and calpain-2 and secreted levels of the proangiogenic proteins intercellular adhesion molecule-1, vascular cell adhesion protein-1, and VEGF. | |||||||||||||||||||||
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References
Keywords
