154540-49-5
154540-49-5
Chemical Structure
Fluoroclebopride
- CAS No.: 154540-49-5
- Formula:C20H23ClFN3O2
- Molecular Weight:391.87
IUPAC Name: 4-amino-5-chloro-N-(1-(4-fluorobenzyl)piperidin-4-yl)-2-methoxybenzamide
InChIKey: HKDIGEWWDHALIS-UHFFFAOYSA-N
SMILES: O=C(NC1CCN(CC2=CC=C(F)C=C2)CC1)C3=CC(Cl)=C(N)C=C3OC
Biological Activity: Fluoroclebopride is a Dopamine receptor ligand with a binding Ki of 0.95 nM for the dopamine D2 receptor and a binding Ki of 5.46 nM for the dopamine D3 receptor. When radiolabeled with 18F, Fluoroclebopride can be used to detect the availability of dopamine D2 and D3 receptors in the caudate nucleus and putamen of primates[1][2].
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Fluoroclebopride | 99.90% | Fluoroclebopride is a Dopamine receptor ligand with a binding Ki of 0.95 nM for the dopamine D2 receptor and a binding Ki of 5.46 nM for the dopamine D3 receptor. When radiolabeled with 18F, Fluoroclebopride can be used to detect the availability of dopamine D2 and D3 receptors in the caudate nucleus and putamen of primates. | ||||||||||||||||||||
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References
- [1]. Czoty PW, et al. Effects of repeated treatment with the dopamine D2/D3 receptor partial agonist aripiprazole on striatal D2/D3 receptor availability in monkeys. Psychopharmacology. 2013 Sep 29. [Content Brief]
- [2]. Nader MA, et al. PET imaging of dopamine D2 receptors in monkey models of cocaine abuse: genetic predisposition versus environmental modulation. The American journal of psychiatry. 2005 Aug;162(8):1473-82. [Content Brief]
