157230-67-6
Chemical Structure
DEPMPO
- CAS No.: 157230-67-6
- Formula:C9H18NO4P
- Molecular Weight:235.22
IUPAC Name: 2-(diethoxyphosphoryl)-2-methyl-3,4-dihydro-2H-pyrrole 1-oxide
InChIKey: OKCDBZSDRSXFIB-UHFFFAOYSA-N
SMILES: [O-][N+]1=CCCC1(C)P(OCC)(OCC)=O
Biological Activity: DEPMPO is a phosphorus-substituted nitrone spin trap probe that can capture superoxide anions and hydroxyl radicals. DEPMPO forms stable spin adducts with hydroxyl, aryl, sulfite and superoxide radicals, and the formation of these adducts can be inhibited by catalase or superoxide dismutase. DEPMPO is rapidly absorbed after intraperitoneal injection and distributes uniformly in the liver, heart and blood of mice. DEPMPO can be used in studies related to oxygen radical detection[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
DEPMPO | 99.84% | DEPMPO is a phosphorus-substituted nitrone spin trap probe that can capture superoxide anions and hydroxyl radicals. DEPMPO forms stable spin adducts with hydroxyl, aryl, sulfite and superoxide radicals, and the formation of these adducts can be inhibited by catalase or superoxide dismutase. DEPMPO is rapidly absorbed after intraperitoneal injection and distributes uniformly in the liver, heart and blood of mice. DEPMPO can be used in studies related to oxygen radical detection. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Liu R, et al. Increased mitochondrial antioxidative activity or decreased oxygen free radical propagation prevent mutant SOD1-mediated motor neuron cell death and increase amyotrophic lateral sclerosis-like transgenic mouse survival. Journal of neurochemistry. 2002 Feb;80(3):488-500. [Content Brief]
- [2]. Qi W, et al. Spin Trapping Hydroxyl and Aryl Radicals of One-Electron Reduced Anticancer Benzotriazine 1,4-Dioxides. Molecules (Basel, Switzerland). 2022 Jan 26;27(3):812. [Content Brief]
- [3]. Liu KJ, et al. Evaluation of DEPMPO as a spin trapping agent in biological systems. Free radical biology & medicine. 1999 Mar;26(5-6):714-21. [Content Brief]
- [4]. Saito K, et al. Comparison of superoxide detection abilities of newly developed spin traps in the living cells. Free radical research. 2009 Jul;43(7):668-76. [Content Brief]
- [5]. Frejaville C, et al. 5‑(Diethoxyphosphoryl)‑5‑methyl‑1‑pyrroline N‑oxide: A New Efficient Phosphorylated Nitrone for the in Vitro and in Vivo Spin Trapping of Oxygen‑Centered Radicals. Journal of Medicinal Chemistry, 1995, 38(2): 258‑265.
Keywords
