158437-84-4
Chemical Structure
ETS transcription factor-IN-1
- CAS No.: 158437-84-4
- Formula:C24H25F2N5O
- Molecular Weight:437.49
InChIKey: PGJDQMYHNOXAEZ-UHFFFAOYSA-N
SMILES: O=C1C2=CN(C3CC3)C4=C(C2=NN1CCN(C)C)C=C(F)C(C5=CC(C)=NC(C)=C5)=C4F
Biological Activity: ETS transcription factor-IN-1 is an inhibitor of ETS transcription factor. ETS transcription factor-IN-1 blocks the binding of the ETS DNA-binding domain to consensus ETS DNA-binding sites, thereby inhibiting the function of ETS transcription factors such as ETV6, ERG, and FLI1. ETS transcription factor-IN-1 inhibits angiogenesis and tumor cell proliferation in cancer cell lines with ETS abnormalities. ETS transcription factor-IN-1 can be used in research related to prostate cancer and breast cancer[1].
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ETS transcription factor-IN-1 | ETS transcription factor-IN-1 is an inhibitor of ETS transcription factor. ETS transcription factor-IN-1 blocks the binding of the ETS DNA-binding domain to consensus ETS DNA-binding sites, thereby inhibiting the function of ETS transcription factors such as ETV6, ERG, and FLI1. ETS transcription factor-IN-1 inhibits angiogenesis and tumor cell proliferation in cancer cell lines with ETS abnormalities. ETS transcription factor-IN-1 can be used in research related to prostate cancer and breast cancer. | |||||||||||||||||||||
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