1586041-58-8
1586041-58-8
Chemical Structure
GDC-0570
Synonym(s): NB004
- CAS No.: 1586041-58-8
- Formula:C20H20F3N5O2S
- Molecular Weight:451.47
InChIKey: PIBVQGPNQNIACT-IOASZLSFSA-N
SMILES: O=C(C1=CSC(C2=C(C=CC=C2F)F)=N1)NC3=C([C@@H]4CC[C@H]([C@@H](CO4)F)N)N(N=C3)C
Biological Activity: GDC-0570 is a novel, potent, selective, orally active pan-PIM inhibitor. GDC-0570 demonstrates synergistic antitumor efficacy when combined with Sotorasib (HY-114277) in acquired KRASis-resistant NSCLC[1].
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GDC-0570 | GDC-0570 is a novel, potent, selective, orally active pan-PIM inhibitor. GDC-0570 demonstrates synergistic antitumor efficacy when combined with Sotorasib (HY-114277) in acquired KRASis-resistant NSCLC. | |||||||||||||||||||||
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References
Keywords
