1590403-33-0
1590403-33-0
Chemical Structure
GDC-3280
Synonym(s): AK3287; AKEX0011
- CAS. Nr.: 1590403-33-0
- Formula:C18H14F3N5O2
- Molecular Weight:389.33
InChIKey: ZJBCIWSBSPECFD-UHFFFAOYSA-N
SMILES: O=C1C2=C(C(C3=CN(C)N=C3)=CN1C4=CC=C(C=C4)OC(F)(F)F)N(C)C=N2
Biological Activity: GDC-3280 (AK3287; AKEX0011) is an orally active compound based on Pirfenidone (HY-B0673)'s phenyl pyridone scaffold. GDC-3280 alleviates the inflammatory and fibrotic reaction of silicosis by inhibiting the ASK1-p38 MAPK pathway and regulating macrophage polarization. GDC-3280 exhibits anti-inflammatory and anti-fibrotic effects[1].
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GDC-3280 | 98.82% | GDC-3280 (AK3287; AKEX0011) is an orally active compound based on Pirfenidone (HY-B0673)'s phenyl pyridone scaffold. GDC-3280 alleviates the inflammatory and fibrotic reaction of silicosis by inhibiting the ASK1-p38 MAPK pathway and regulating macrophage polarization. GDC-3280 exhibits anti-inflammatory and anti-fibrotic effects. | ||||||||||||||||||||
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