159730-07-1
159730-07-1
Chemical Structure
LY-272015
- CAS No.: 159730-07-1
- Formula:C21H24N2O2
- Molecular Weight:336.43
IUPAC Name: 1-(3,4-dimethoxybenzyl)-6-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
InChIKey: GDAJGLDMCDMPIR-UHFFFAOYSA-N
SMILES: CC1=CC2=C(NC3=C2CCNC3CC4=CC=C(OC)C(OC)=C4)C=C1
Biological Activity: LY-272015 is an orally active, specific 5-HT2B receptor antagonist. LY-272015 completely inhibits the phosphorylation of ERK2 induced by 5-HT or BW723C86. LY-272015 is antihypertensive in Deoxycorticosterone Acetate (DOCA)-salt-hypertensive rats[1][2].
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LY-272015 | LY-272015 is an orally active, specific 5-HT2B receptor antagonist. LY-272015 completely inhibits the phosphorylation of ERK2 induced by 5-HT or BW723C86. LY-272015 is antihypertensive in Deoxycorticosterone Acetate (DOCA)-salt-hypertensive rats. | |||||||||||||||||||||
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References
- [1]. S W Watts, et al. 5-HT2B-receptor antagonist LY-272015 is antihypertensive in DOCA-salt-hypertensive rats. Am J Physiol. 1999 Mar;276(3):H944-52. [Content Brief]
- [2]. Kota Naito, et al. Signal Transduction Mechanism for Serotonin 5-HT2B Receptor-Mediated DNA Synthesis and Proliferation in Primary Cultures of Adult Rat Hepatocytes. Biol Pharm Bull. 2016;39(1):121-9. [Content Brief]
